Evaluation of Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy

Key Inclusion Criteria: * Before Surgery * Participants scheduled to undergo a primary unilateral bunionectomy with distal first metatarsal osteotomy (i.e., Austin procedure) and internal fixation under regional anesthesia (Mayo and popliteal sciatic block) * After Surgery * Participant is lucid and able to follow commands * All analgesic guidelines were followed during and after the bunionectomy Key Exclusion Criteria: * Before Surgery * Prior history of bunionectomy or or other foot surgery on the index foot; or bunionectomy on the opposite foot * History of cardiac dysrhythmias within the last 2 years requiring anti-arrhythmia treatment(s) * Any prior surgery within 1 month before the first study drug dose * After Surgery * Participant had a type 3 deformity requiring a base wedge osteotomy, concomitant surgery such as hammertoe repair; or experienced medical complications during the bunionectomy * Participant had a medical complication during the bunionectomy that, in the opinion of the investigator, should preclude randomization Other protocol defined Inclusion/Exclusion criteria may apply.