Efficacy and Safety Of Different Regimens In Patients With Type 2 Diabetes Receiving Intensive Insulin Therapy

Inclusion Criteria: * aged 18-70 years with poorly-controlled T2DM (World Health Organization diagnostic criteria) * BMI 21\~32Kg/m2 * duration of T2DM more than 1 year * FPG≥11.1mmol/L or HbA1c ≥9% for three months * fasting C-peptide \>1 ng/mL Exclusion Criteria: * acute diabetic complications (diabetic ketoacidosis, lactic acidosis, hyperosmolar nonketotic diabetic coma) within the past 1 month; * impaired renal function,defined as (but not limited to) serum creatinine levels ≥1.5 mg/dL for males and ≥1.4 mg/dL for females, or the presence of macroproteinuria (\> 2 g/day) * pregnancy * inability to perform self-monitoring of BG (SMBG) * acute disease or surgery in the past 3months or preparation for the surgey