The purpose of this study is to evaluate safety and tolerability and to determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and/or recommended dose (RD) of SGR-1505.
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Nature, severity, and number of incidences of adverse events (AEs), serious AEs (SAEs), and AEs leading to treatment discontinuation.
Timeframe: Throughout the study, up to 2 years.
Nature and number of incidences of dose limiting toxicity (DLT).
Timeframe: The first 21 days.