[18F]APN-1607 PET in Subjects With AD Compared to HC

Inclusion Criteria: Inclusion Criteria for All Subjects: * Written informed consent must be obtained before any assessment is performed. * Female subjects must be documented by medical records or physician's note to be either surgically sterile (by means of hysterectomy, bilateral oophorectomy, or tubal ligation) or post-menopausal for at least 1 year (ie, 12 consecutive months with no menses without an alternative medical cause) or, if they are of childbearing potential, must commit to use a barrier contraception method or to abstinence for the duration of the study and must have negative serum and urine pregnancy tests. * Male subjects and their partners of childbearing potential must commit to the use of two methods of contraception, one of which is a barrier method (ie, condom), or to abstinence for the study duration. * Male subjects must not donate sperm for the study duration. * Willing and able to participate in all study procedures. Inclusion Criteria for Healthy Subjects: * Medically healthy with no clinically relevant finding on physical examination, laboratory profiles, VS, or ECG at screening and upon reporting for the \[18F\]APN-1607 Imaging Visit. * No cognitive impairment based on neuropsychological battery and as judged by the Investigator. * No first-degree family history of early-onset AD or other neurological disease associated with dementia (prior to age 65). Inclusion Criteria for Subjects with MCI: * Written informed consent must be obtained befor…