Flapless Application of Enamel Matrix Derivative in Class II Mandibular Furcation Defects

Inclusion Criteria: * Individuals of at least 18 years of age with a diagnosis of stage III or IV periodontitis. * Have at least one class II furcation defect with PPD \>4 mm and horizontal probing depth of \>= 3 mm in a mandibular first or second molar. * Teeth have to be vital or properly treated endodontically. * Gingival recession ≤ 2mm on furcation site * Proper oral hygiene: full-mouth plaque score (FMPS) ≤20%. * Systemically healthy (absence of systemic conditions such as diabetes mellitus that can affect the treatment outcome of periodontal therapy) * Ability to understand the study procedures and comply with them through the length of the study. * Given written informed consent form for participation in the study. Exclusion Criteria: * Pregnant or lactating female (self-reported). * Current acute infection. * Non-surgical periodontal treatment within the last 6 months or/and surgical periodontal treatment the last 12 months before the initial pre-treatment. * Need for antibiotic premedication. * Antibiotic treatment in the previous 3 months. * Allergy to any materials or medications that could be used during or after the procedure. * Teeth having an improper endodontic therapy with clinical signs of infection or subgingival restorations. * Tooth mobility of 2nd and 3rd degree. * History of radiation therapy in the head and neck region. * Chronic use of medications that may alter the response of periodontal tissues. * Smoke ≥ 10 cigarettes/day.