Understanding the Role of Gut Microbiota in Hyperphagia in Prader-Willi Syndrome

Inclusion Criteria: * Aged between 18-35 (inclusive) * Confirmed PWS with genetic testing * No growth hormone treatment in the previous 6 months * Body weight \< 300 lbs. Exclusion Criteria: * History of other gastrointestinal disorders such as small intestinal bacterial overgrowth, celiac disease, inflammatory bowel disease, or irritable bowel syndrome. * Pregnancy or breastfeeding * Prior gastrointestinal or bariatric surgery * Immunocompromised e.g., cancer treatment, bone marrow/organ transplant, immune deficiency, poorly controlled HIV/AIDS, prolonged use of steroids or other immunosuppressant medications * Antibiotic administration in the previous 30 days * Participation in other weight-loss programs in the previous 3 months. * Administration of pre/probiotic supplements or antibiotics. * Growth hormone administration in the previous 6 months * Must have access to a smartphone, tablet, computer, or other qualifying internet-enabled device and be able to follow instructions. * Individuals who are not proficient in English * Contraindications for MRI scanning, including Ferrous material implanted in or on the body, including flakes or filings, surgical clips, bullets, or electrical devices such as a pacemaker, or nonremovable ferrous jewelry (fillings in teeth and permanent retainers are permitted). Individuals with surgical pins or plates above the neck are excluded. Surgical pins or plates below the neck are exclusions, except when the material is fixed to bone, and …