Stopped: Sponsor decision to terminate study.
Master protocol: The goal of this master clinical study is to test how well the study drug, brexucabtagene autoleucel, works in participants with rare B-cell malignancies: relapsed/refractory Waldenstrom macroglobulinemia (r/r WM) (Substudy A), r/r Richter transformation (RT) (Substudy B), r/r Burkitt lymphoma (BL) (Substudy C) and r/r hairy cell leukemia (HCL) (Substudy D).
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Substudy A: Combined Rate of Complete Response (CR) and Very Good Partial Response (VGPR) Determined by Central Assessment Per the Sixth International Workshop in Waldenstrom Macroglobulinemia (WM)
Timeframe: Up to 2 years
Substudy B: Objective Response Rate (ORR) Determined by Central Assessment Per the Lugano Classification
Timeframe: Up to 2 years
Substudy C: ORR Determined by Central Assessment Per the Lugano Classification
Timeframe: Up to 2 years
Substudy D: ORR Determined by Central Assessment Per the Response Criteria Described by Grever and Colleagues
Timeframe: Up to 2 years