Evaluation of the Early Bactericidal Activity of Tedizolid and Linezolide Against Mycobacterium Tuberculosis (TEDITUB)

Inclusion Criteria: * Age ≥ 18 years old and \<75 years old * Woman on childbearing age should be on effective contraception during the duration of the study and up to 6 months after treatment; a mechanical contraception (use of condom) will be strongly recommended * Male (effective contraception must be used during duration of the study and up to 3 months after treatment) * Patient with a first infection with Mycobacterium tuberculosis of pulmonary localization suspected by the presence of a clinical pulmonary symptomatology, a chest X-ray or an abnormal chest computed tomography, and the positive microscopic examination of a sputum (AFB +, presence of AFB) with confirmation of tuberculosis by a genotypic test demonstrating no resistance to rifampicin, without clinical signs of extra-thoracic involvement * State medical assistance application being processed ( If patient does not benefit from social security), * Signature of informed consent Exclusion Criteria: * Resistance to one of the anti-tuberculosis drugs used detected by a genotypic test in accordance with the recommendations of the High Council of Public Health of 2015; * History of anti-tuberculosis treatment (patients with a documented negative genotypic test for isoniazid and rifampicin resistance may be included) * History of treatment in the previous two years with one of the antibiotics evaluated in this trial lasting more than one month; * Absolute contraindication to the use of at least one of the test mol…