Comparison of Two Strategies of One-lung Ventilation in Patients Undergoing Carcinological Lung Resection Surgery.

Inclusion Criteria: * To be over 18 years old, * To be able to attend all scheduled visits and to comply with all trial procedures, * To be scheduled for a lung cancer resection surgery (performed by either video-assisted thoracoscopy or thoracotomy). Exclusion Criteria: * Non-carcinologic indication of lung resection (e.g. Lung volume reduction for bullous emphysema reduction, lung abscess), * Bilateral pulmonary resection surgery or history of lung resection surgery, * Lung resection under sternotomy * Non intubated video-assisted thoracoscopy * Robotic thoracic surgery * Contraindication to esophageal catheter (history of esophageal varices, hepatic cirrhosis child ≥ b, esophageal or gastric surgery, thoracic radiotherapy, latex allergy), * ASA (American Society of Anesthesiologists) score ≥ 4, * Chronic obstructive pulmonary disease GOLD III or IV (Forced Expiratory Volume, FEV\<50%), * Uncontrolled asthma (FEV \<50%), * Intracardiac shunt, * Hemoglobinopathy making the SpO2 values invalid, * Heart failure NYHA III or IV, * Documented pulmonary hypertension (Mean Pulmonary Arterial Pressure at rest, mPAP\>20 mmHg), * To be under legal protection, * Unable to read or write, * Lack of informed consent, or unable to give consent, * Refusal to participate in the study, * Pregnancy in progress or planned during the study period, pregnant or nursing women, * Not being affiliated to a French social security system or being a beneficiary of such a system.