Intradermal Acupuncture Based on Changes in Biological Specificity of Acupoints for Major Depressive Disorder

Inclusion Criteria: Inclusion criteria for HC: * HC who could provide a recent depression screening report, and confirm they have not any cardiovascular, respiratory, digestive, urinary, hematological, endocrine, or neurological disease; * 18 ≤ age ≤60 years, male or female; * Participants have clear consciousness and could communicate with others normally; * Participants could understand the full study protocol and have high adherence. Written informed consent is signed by themselves. Inclusion criteria for MDD: * Patients should meet the diagnostic criteria of the International Classification of Diseases 10th Edition (ICD-10) diagnostic criteria for MDD; * 18 ≤ age ≤60, male or female; * Participants have clear consciousness and could communicate with others normally; * Participants could understand the full study protocol and have high adherence. Written informed consent is signed by themselves. Exclusion Criteria: Exclusion criteria of HC: * Participants with serious primary diseases of cardiovascular diseases, liver diseases, kidney diseases, urinary diseases, and hematological diseases; * Participants have a mental illness, alcohol dependence, or a history of drug abuse; * Pregnant or lactating participants; * Participants with intellectual disabilities who cannot cooperate with the questionnaire survey; * Participants with bleeding tendency, skin disease, allergic constitution, and allergic to adhesive tape; * The skin at the test site of participants has scars,…