Study of AT-02 in Healthy Volunteers and Subjects With Systemic Amyloidosis

Inclusion criteria

• ✓. Understands the study procedures and can give signed informed consent
• ✓. Male or female between \>18 and \<56 years of age.
• ✓. Willing and able to comply with this protocol and informed consent and be available for the entire duration of the study.
• ✓. Willing to abstain from alcohol and strenuous physical activity (i.e., strenuous or unaccustomed weightlifting, running, bicycling, etc.) from 48 hours prior to study treatment administration until discharge from the clinical unit and prior to each outpatient visit.
• ✓. In good general health, determined by no clinically significant findings in the opinion of the Investigator from medical history, physical examination, 12-lead electrocardiogram (ECG), clinical laboratory findings, and vital signs at Screening and Phase 1 unit Check-in.
• ✓. Has body mass index (BMI) of 18 to 32 kg/m2, inclusive.
• ✓. Women of childbearing potential (WOCBP)
• ✓. WOCBP must have a negative serum or urine pregnancy test within 24 hours prior to the start of study drug.