Parkinson disease (PD) is a common disorder in which reduced speed of movement results from inadequate brain production of the chemical dopamine. The most effective treatment for Parkinson disease is the use of drugs that provide dopamine replacement therapy (DRT). However, as the disease progresses there are prominent DRT-resistant features of Parkinson disease that are a major source of disability. These include cognitive (attention, memory) impairments and gait disorders such as freezing and falls. Repetitive transcranial magnetic stimulation (rTMS), a form of non-invasive brain stimulation, holds promise for the study and treatment of motor and cognitive deficits in persons with Parkinson's. To date, there are no conclusive results regarding an optimal rTMS protocol for recovery of motor and cognitive deficits in Parkinson's disease. This study is designed to promote clinical rehabilitation neuroscience research, and aims to improve rehabilitation in persons with Parkinson's with freezing of gait. This work will evaluate the use of a new accelerated, high dose, non-invasive brain stimulation method for treatment of freezing of gait in PD and will test how applying targeted accelerated stimulation to the brain improves gait disturbance due to PD.
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Participant perception of treatment acceptability
Timeframe: up to six treatment days
Retention rate
Timeframe: Change from Baseline prior to treatment and at follow-up within 1 week post-treatment
Percentage change in TUG test time to 48 hours and 14 days post-intervention
Timeframe: Change from Baseline; 48 hours post; 14 days post -intervention
Net changes in FOG-Q scores at 48 hours and 14 days post-intervention
Timeframe: Change from Baseline; 48 hours post; 14 days post -intervention