The purpose of the study is to monitor safety and to evaluate the efficacy of a probiotic formulation on abdominal pain, abnormal defecation, comorbid mood disorders (anxiety and depression) as well as general quality of life in adults with IBS-D.
Who can participate
Age range18 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Experiencing symptoms of IBS-D
* Having a diagnosis of IBS-D based on Rome IV criteria
* Participants with symptom onset at least 6 months before diagnosis
* Having a normal colonoscopy result in their medical file
Exclusion Criteria:
* A history of inflammatory or immune-mediated gastrointestinal diseases
* Diagnosed with a co-existing organic gastrointestinal disease which can affect the study
* Currently undergoing a treatment for other severe conditions such as coronary disease, neurological disorder, kidney or liver disease,
* Currently diagnosed with an eating disorder,
* Having undergone any abdominal surgery including cholecystectomy, with the exception of hernia repair or appendectomy
* Currently diagnosed with any mood- or anxiety-related disorder, major psychiatric illness, or participants with a history of suicidal ideation, or current suicidal ideation,
* Regular use of anti-diarrhea medications and laxatives however occasional use is permitted (≤ than once a month); if current use is \> once per month a one month wash out is needed,
* Unwilling to avoid the use of antidiarrheal or laxative medication on an "as-needed basis" during the full length of the study,
* Pregnant, breast-feeding or planning on becoming pregnant.