Efficacy and Safety of Pirfenidone in CTD-ILD

Exclusion criteria

• ✕. Liver :AST, ALT, R-GT, bilirubin at 1.5 ULN, or previously diagnosed viral hepatitis;
• ✕. Kidney: creatinine clearance rate 30ml /min;
• ✕. Lung: airway obstruction (pre-bronchodilator FEV1/FVC \& LT; 0.7), pleural effusion accounted for more than 20% of pleural effusion, severe pulmonary infection or other clinically significant pulmonary abnormalities;
• ✕. Cardiovascular: myocardial infarction within 6 months;
• ✕. gastrointestinal tract: active peptic ulcer or bleeding;
• ✕. Blood system: severe anemia, leukopenia, thrombocytopenia;
• ✕. Nervous system: patients with mental disorders; Cerebral thrombotic events (stroke and transient ischemic attack) within the last 1 year;