Parkinson's Disease (PD) is often accompanied by non-motor symptoms that make treatment more difficult. One such symptom is apathy (lack of motivation and emotion). There are no treatments for apathy in PD, and this remains a major unmet need in PD patients. One possible way to target apathy in PD patients is listening to music, which has been shown to help improve apathy in older adults. Little work has explored the mechanism in which music targets apathy. Thus, the goal of this study is to understand how music listening can impact the brain towards decreasing apathy in PD patients.
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Change in seed-based functional connectivity between auditory, reward, and motor areas (implicated in musical reward processing) during a music-listening task, before and after an 8-week audio-based intervention
Timeframe: 8 weeks
Change in seed-based functional connectivity between auditory, reward, and motor areas (implicated in musical reward processing) at rest, before and after an 8-week audio-based intervention
Timeframe: 8 weeks
Change in univariate whole-brain analysis at rest before and after an 8-week audio-based intervention
Timeframe: 8 weeks
Change in univariate whole-brain analysis during a music listening task before and after an 8-week audio-based intervention
Timeframe: 8 weeks
Change in fMRI representational similarity analysis during a music listening task before and after an 8-week audio-based intervention
Timeframe: 8 weeks
Change in fMRI representational similarity analysis at rest before and after an 8-week audio-based intervention
Timeframe: 8 weeks
Short-term clinical measure of apathy before and after an 8-week audio-based intervention -Positive and Negative Affective Schedule (PANAS)
Timeframe: 8 weeks
Short-term clinical measure of apathy after a 4-week washout period post-intervention - Positive and Negative Affective Schedule (PANAS)
Timeframe: 4 weeks
Short-term clinical measure of apathy before and after an 8-week audio-based intervention - Visual Analogue Scale (VAS)
Timeframe: 8 weeks
Short-term clinical measure of apathy after a 4-week washout period post-intervention - Visual Analogue Scale (VAS)
Timeframe: 4 weeks
Long-term clinical measure of apathy before and after an 8-week audio-based intervention - Starkstein Apathy Scale (SAS)
Timeframe: 8 weeks
Long-term clinical measure of apathy after a 4-week washout period post-intervention - Starkstein Apathy Scale (SAS)
Timeframe: 4 weeks
Clinical assessment of apathy before and after an 8-week audio-based intervention - Lille Apathy Rating Scale (LARS)
Timeframe: 8 weeks
Clinical assessment of apathy after a 4-week washout period post-intervention - Lille Apathy Rating Scale (LARS)
Timeframe: 4 weeks
Clinical assessment of apathy in Parkinson's Disease before and after an 8-week audio-based intervention - Movement Disorders Society Unified Parkinson's Disease Rating Scale - apathy item (MDS-UPDRS)
Timeframe: 8 weeks
Clinical assessment of apathy in Parkinson's Disease after a 4-week washout period post-intervention - Movement Disorders Society Unified Parkinson's Disease Rating Scale - apathy item
Timeframe: 4 weeks
Assessment of musical reward sensitivity before and after an 8-week audio-based intervention - Barcelona Musical Reward Questionnaire (BMRQ)
Timeframe: 8 weeks
Assessment of musical reward sensitivity after a 4-week washout period post-intervention - Barcelona Musical Reward Questionnaire (BMRQ)
Timeframe: 4 weeks
Grip force response (GFR) during a music listening fMRI task before and after an 8-week audio-based intervention
Timeframe: 8 weeks
Grip force duration and fatigue during a music listening fMRI task before and after an 8-week audio-based intervention
Timeframe: 8 weeks