This randomized controlled trial aimed to evaluate the effect of interscalene brachial plexus block (ISB) on early postoperative wound healing and perioperative biological responses in patients undergoing open rotator cuff repair. Participants were randomly allocated to receive either ultrasound-guided interscalene brachial plexus block combined with standardised general anaesthesia (ISB+GA) or standardised general anaesthesia alone (GA). The primary outcome was early wound healing assessed using the Toronto Symptom Assessment System for Wounds (TSAS-W) on postoperative days 5 and 14. Secondary outcomes included perioperative serum cytokine and growth factor levels (IL-1β, IL-2, TNF-α, EGF, PDGF, TGF-β), platelet counts, postoperative pain scores, opioid consumption, time to mobilisation, and postoperative nausea and vomiting. The study hypothesis was that ISB would improve early wound healing and promote a pro-regenerative biomarker profile compared with GA.
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Early postoperative wound healing (TSAS-W score)
Timeframe: Postoperative day 5 and day 14