Effectiveness and Safety of Therapy Based on Attenuated ATO Plus Low-Dose ATRA in Patients With APL

Inclusion Criteria: * Age \>18 years * Both genders * new diagnosis of APL * Diagnosis of relapsed APL who have not been previously treated with ATO * Morphological diagnosis of APL confirmed by PCR or FISH Exclusion Criteria: * Poor functional status (ECOG\>2) * Organic dysfunction (Marshall score ≥2) * Pregnancy * Heart failure (NYHA III or IV) * Renal failure (GFR \<30 ml/min/1.72m2) * History of ventricular arrhythmias or uncontrolled arrhythmias * Acute myocardial infarction, unstable angina, or stable angina in the last six months * Uncontrolled active infection * Liver disease (Child-Pugh C)