The purpose of this study is to identify the recommended Phase 2 combination dose (RP2CD\[s\]) of the amivantamab and capmatinib combination therapy in participants with non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection), and to evaluate the antitumor effect of the amivantamab and capmatinib combination therapy in mesenchymal-epithelial transition (MET) exon 14 skipping mutation and MET amplified NSCLC, when administered at the selected RP2CD(s) in Phase 2 (expansion).
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Phase 1: Number of Participants with Adverse events (AEs) by Severity
Timeframe: Up to 2 years 1 month
Phase 1: Number of Participants with Dose Limiting Toxicities (DLTs)
Timeframe: Cycle 1 (Day 1 through Day 28)
Phase 2: Objective Response Rate
Timeframe: Up to 2 years 1 month