CompletedNot Applicable

A Study of Detergents in the Pathogenesis of Eosinophilic Esophagitis

United States12 participantsStarted 2022-09-12

Plain-language summary

The purpose of this research is to determine if detergents in everyday products such as toothpaste make the lining of the esophagus leaky and cause allergic inflammation.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Normal, healthy volunteers. * Able to swallow pills. Exclusion Criteria: * Personal history of esophageal disease including but not limited to eosinophilic esophagitis, esophageal dysmotility, or GERD/reflux. * History of dysphagia (i.e., difficulty swallowing), chronic vomiting, chronic abdominal pain, unintentional weight loss. * Celiac disease, inflammatory bowel disease, irritable bowel syndrome, esophageal varices, chronic aspiration, connective tissue disorder, or known parasitic infection. * Gelatin allergy. * Use of a toothpaste containing SLS within 2 weeks of the study. * Pregnancy.

What they're measuring

Change in Mucosal impedance 15 minutes after exposure

Timeframe: Baseline, 15 minutes after teeth brushing

Trial details

NCT IDNCT05482256

SponsorMayo Clinic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-02-10

View on ClinicalTrials.gov More Eosinophilic Esophagitis trials