Effects of Acute Pain on Motor Learning in Young vs Older Adults (NCT05471557) | Clinical Trial Compass
CompletedNot Applicable
Effects of Acute Pain on Motor Learning in Young vs Older Adults
United States61 participantsStarted 2024-08-20
Plain-language summary
To date, the effects of pain on motor learning have not been thoroughly investigated, particularly in older adults. Broadly, the purpose of this research is to investigate the impact of acute pain on locomotor learning and its retention in older adults. The investigators hypothesize that acute pain impairs retention of locomotor learning in young and older adults and that in older adults, these deficits are worsened and are related to the degree of normal age-related cognitive decline.
Who can participate
Age range18 Years ā 85 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
ā. 18-35 (YA group only) or 55-85 (OA group only) years old
ā. Sex-matched to a participant in the OA group (YA group only)
ā. Self-identifying as generally medically healthy
ā. Able to read, write and speak English
ā. Able to provide informed consent and attend all testing sessions
ā. Willing to undergo the experimental pain or non-painful electrical stimulation, if selected
Exclusion criteria
ā. Resting HR \< 50 or \> 100 bpm
ā. Resting BP \< 90/60 or \> 140/95 mmHg (YA group only) or \> 165/95 (OA group only)
ā. Any history or current mental health condition, learning/developmental disability or cognitive impairment, including severe untreated ADD/ADHD, severe untreated anxiety, severe untreated depression, autism spectrum disorder, insomnia, mild cognitive impairment, etc.
ā. Score on the MoCA \<23
ā. Score on the GAD-7 ā„ 10
ā. Score on the PHQ-2 ā„ 2 and score on the PHQ-9 ā„ 10
ā. Any current (within last 3 month) or chronic medical conditions, including any musculoskeletal, cardiovascular, endocrine, pulmonary, metabolic, psychiatric or neurological diagnosis that (for OA group only) affects activities of daily living or would confound testing or place the subject at risk by participating, such as a significant cardiovascular condition or event (e.g., heart attack \< 3 months ago, uncontrolled atrial fibrillation, uncontrolled angina, or congestive heart failure, chronic obstructive pulmonary disorder, peripheral vascular disease)
What they're measuring
1
Motor Retention Magnitude
Timeframe: 24 hours post learning (day 2)
2
Motor Learning Magnitude
Timeframe: immediately after learning (day 1)
3
Digit Span Backward Test
Timeframe: the change between baseline and during application of intervention
4
Digit Span Forward Test
Timeframe: the change between baseline and during application of intervention