Clinical Study of ABCD in the Treatment of Cryptococcal Meningitis

Inclusion Criteria: * ≥18 years old and ≤70 years old, no gender limitation; * Diagnosis of cryptococcal meningitis (with or without other cryptococcal lesions) based on CSF culture and/or CSF ink staining smear and/or CSF antigen testing; * The researcher believes that patients can benefit from participating in this study; * The subjects voluntarily participated in the study and signed the informed consent. Exclusion Criteria: * Patients with other invasive fungal diseases; * HIV infected patients; * Patients who received intravenous polyene treatment within the past 6 months; * Allergic to Amphotericin B Colloidal Dispersion or other ingredients in this product; * Patients with abnormal liver function \[aspartate aminotransferase (AST) or alanine aminotransferase (ALT) \>＝5 times the upper limit of normal value (ULN) without total bilirubin elevation, or ALT or AST \>＝ 3 times ULN with total bilirubin \>＝ 1.5 times\]; * Patients with impaired renal function (renal function index blood creatinine (Cr) is more than 2 times higher than ULN, or 24-hour urine creatinine clearance rate （Ccr） is less than 50ml/min), or patients requiring/undergoing hemodialysis or peritoneal dialysis; * Pregnant women, breast-feeding women and women of childbearing age who were unable to take effective contraceptive measures during the study period; * Conditions considered unsuitable for the study by the investigator, such as concomitancy of severe organ insufficiency, clinically significant la…