Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patient… (NCT05467332) | Clinical Trial Compass
UnknownNot Applicable
Tracheal Positive Pressure During High Flow Nasal Oxygen Administration in Critically Ill Patients: a Physiologic Study.
Italy20 participantsStarted 2023-04
Plain-language summary
High flow nasal cannula administration in critically ill patients is frequently used to improve acute respiratory failure or to prevent respiratory failure after extubation.
It acts generating a mild positive pressure in the airways and by reducing respiratory effort of patients.
However to the best of our knowledge, no study to date has directly measured the amount of positive pressure generated in the trachea of patients.
The primary aim, therefore, of this study measures this positive pressure after extubation in critically ill patients.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria: CRITICALLY ILL PATIENTS AFTER MECHANICAL VENTILATION LASTED AT LEAST 72 HOURS
* age 18-80 years
Exclusion Criteria:
* COPD stage \>1 according to GOLD classification
* end stage organ disease (liver, kidney, heart, lung)
* neuromuscular disease
* neoplasm
* previous tracheostomy
* obesity with BMI \> 35 Kg/m2
* non collaborative patient
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
HFNC-PEEP
Timeframe: 3 HOURS
Trial details
NCT IDNCT05467332
SponsorAzienda Sanitaria-Universitaria Integrata di Udine