Efficacy, Safety, and Tolerability of LPRI-CF113 as an Oral Contraceptive in Females

Inclusion Criteria: * Subjects must be willing and able to provide written informed consent (for adults) or assent (for adolescents \<18 years of age) and comply with all study procedures, prohibitions, restrictions, and scheduled visits * Subjects must be female, healthy, sexually active, postmenarcheal, premenopausal, and of childbearing potential, between 13 and 45 years of age (inclusive at the time of screening) and at risk for pregnancy * Note: Childbearing potential is defined as subjects who are ovulating, premenopausal, and not surgically sterile (ie, have not undergone hysterectomy, salpingectomy, or bilateral oophorectomy). Subjects that have undergone unilateral oophorectomy will not be considered surgically sterile and may be included in the study * Note: Only subjects 18 to 45 years of age (inclusive at the time of screening) are eligible for inclusion in Part B * Subjects must be willing to have vaginal intercourse (with a genetically male partner) throughout the Treatment Period (ie, during each medication cycle) without using a secondary (eg, spermicides) or emergency method of contraception * Subjects must have a BMI of 18 kg/m2 or higher * Subjects must have a systolic blood pressure of 159 mmHg or lower and a diastolic blood pressure of 99 mmHg or lower * Note: The median of 3 blood pressure measurements will be used for this criterion * Note: Subjects are required to rest for 5 minutes prior to the first blood pressure measurement and for 1 min…