Stopped: Insufficient funds to start study
A randomized, controlled trial to evaluate patient compliance and biologic mechanisms of a short-term pre-operative Protein-Calorie Restriction (PCR) diet in comparison to a normal ad libitum diet for 4 days before elective vascular surgery involving a major operation. After a pilot study exploring the safety and feasibility of the PCR diet conducted inpatient before carotid endarterectomy titled Short-Term Endogenous Hydrogen Sulfide Upregulation, and a follow-up study titled Dietary Restriction in Vascular Surgery, the investigators now aim to expand the study to at home diet among a variety of vascular surgery procedures. This study will further elucidate not only the practicality of pre-operative short term dietary restriction, but also provide early data to inform biologic mechanisms and to inform future efficacy trails.
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Compliance with outpatient Protein-Calorie Restriction measured via food diary
Timeframe: 1 Month
Compliance with outpatient Protein-Calorie Restriction measured via biologic assays for plasma free amino acids
Timeframe: 1 Month
Compliance with outpatient Protein-Calorie Restriction measured via biologic assays for pre-albumin
Timeframe: 1 Month
Compliance with outpatient Protein-Calorie Restriction measured via biologic assays insulin-like growth factor
Timeframe: 1 Month
Change over time from baseline values to values before surgery and day 1 after surgery in the comparison of H2S and standard biological markers of stress in blood
Timeframe: Baseline, Day 0, Day 1
Major Adverse Limb Event
Timeframe: 2 years