YH001 Plus Envafolimab With or Without Doxorubicin in Patients With Advanced or Metastatic Sarcoma (NCT05448820) | Clinical Trial Compass
UnknownPhase 1/2
YH001 Plus Envafolimab With or Without Doxorubicin in Patients With Advanced or Metastatic Sarcoma
United States15 participantsStarted 2022-11-14
Plain-language summary
This is a multicenter, open label, Phase 1/2 study of YH001 initially given in combination with envafolimab, and then given in combination with envafolimab plus doxorubicin in patients with advanced or metastatic sarcoma, followed by Phase 2 cohorts of patients with select histologies of advanced or metastatic sarcoma.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Histologically confirmed advanced or metastatic sarcoma patients without UPS or MFS who are refractory to or intolerant to standard treatments for their disease.
✓. Histologically confirmed advanced or metastatic sarcoma patients without UPS or MFS who have not received any immune checkpoint inhibitors or doxorubicin, and with histology for which doxorubicin is considered a reasonable treatment option (for Cohort 1B, 2B and Expanded Cohort 1B and/or 2B)
✓. Measurable disease by RECIST 1.1
✓. Age ≥ 18 years
✓. Adequate organ function
✓. Left ventricular ejection fraction (LVEF) as measured by echo or multigated acquisition scan of \> 50% (for patients to receive doxorubicin)
✓. Willingness and ability to consent for self to participate in study
✓. Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures
Exclusion criteria
✕. Gastrointestinal stromal tumor (GIST) or desmoid tumors
✕. Condition requiring systemic treatment with either corticosteroids or other immunosuppressive medications within 14 days prior to enrollment
✕. Known allergy to any component of any study drug that the patient would receive if enrolled into this study
What they're measuring
1
Phase 1: Determine recommended phase 2 dose of YH001 in combination with Envafolimab
Timeframe: 8 months
2
Phase 1: Determine recommended phase 2 dose of YH001 in combination with Envafolimab with Doxorubicin
Timeframe: 8 months
3
Phase 2: Determine the objective response rate (ORR) of YH001 in combination with Envafolimab and Doxorubicin
Timeframe: 18 months
4
Phase 2: Determine the objective response rate (ORR) of YH001 in combination with Envafolimab
✕. Prior pericardial or mediastinal radiation (for patients to receive doxorubicin)
✕. Acute coronary syndromes within 6 months of enrollment
✕. Women who are pregnant or breast feeding
✕. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the Investigator, would make the patient inappropriate for this study