Study of AD981 Versus Placebo in Obesity Hypoventilation Syndrome

Inclusion Criteria: * Be able to understand the nature of the study and sign the informed consent * BMI \> 35 kg/m2 and presence of nocturnal hypoventilation * Previous surgical treatment for OSA is allowed if ≥ 1 year prior to enrollment * If in treatment, CPAP or BPAP or mandibular advancement device or positional therapy intolerance or poor compliance Exclusion Criteria: * Narcolepsy, craniofacial malformation, renal failure, hepatic disease, schizophrenia, schizoaffective disorder or bipolar disorder, cognitive dysfunction, severe neurological disorder, pheochromocytoma, adrenocortical insufficiency, hyperchloremic acidosis. * Respiratory (COPD, ILD, oxygen therapy) or cardiac (Heart Failure, Atrial fibrillation, established severe peripheral arterial disease) disease or hypertension requiring more than 3 medications for control * Cardiomyopathies, heart malformation or structural heart alterations, severe rhythm disorders, established coronary heart disease or other cardiac conditions, which could determine sudden death * Attempted suicide or suicidal ideation * Drugs of abuse or substance use disorder * A significant illness or infection requiring medical treatment in the past 30 days. * Untreated narrow angle glaucoma. * Women who are pregnant or nursing. * Treatment with strong cytochrome P450 3A4 (CYP3A4) inhibitors, or monoamine oxidase inhibitors (MAOI) or linezolid within 14 days of the start of treatment, allergies to sulfonamides. * Diabetes with unstable glu…