The purpose of this first-time-in-human (FTiH) study is to assess the safety, reactogenicity and immunogenicity of GlaxoSmithKline's (GSK) messenger RNA (mRNA)-based monovalent vaccine (GSK4382276A) candidate against influenza in healthy younger adults (YA) and older adults (OA).
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Number of Participants Reporting Any Solicited Administration Site Events
Timeframe: Day 1 to Day 7
Number of Participants Reporting Any Solicited Systemic Events
Timeframe: Day 1 to Day 7
Number of Participants Reporting Any Unsolicited Adverse Events (AEs)
Timeframe: Day 1 to Day 28
Number of Participants Reporting Serious Adverse Events (SAEs)
Timeframe: Day 1 to Day 183
Number of Participants Reporting AEs of Special Interest (AESIs)
Timeframe: Day 1 to Day 183
Number of Participants Reporting Shift From Abnormal Non-clinically Significant and Normal or Missing Laboratory Value on Day 1 to Clinically Significant Abnormal Laboratory Value on Day 8 for Hematology, Clinical Chemistry, Coagulation and Urine Analysis
Timeframe: At Day 8 compared to baseline (Day 1)
Number of Participants Reporting Shift From Abnormal Non-clinically Significant and Normal or Missing Laboratory Value on Day 1 to Clinically Significant Abnormal Laboratory Value on Day 29 for Hematology,Clinical Chemistry, Coagulation and Urine Analysis
Timeframe: At Day 29 compared to baseline (Day 1)
Geometric Mean Titers (GMT) of Anti-vaccine Antibody Titers
Timeframe: At Day 1
GMT of Anti-vaccine Antibody Titers
Timeframe: At Day 22
Geometric Mean Increase (GMI) of Anti-vaccine Antibody Titers From Day 1 (Baseline) to Day 22
Timeframe: From Day 1 to Day 22
Percentage of Participants With Anti-vaccine Antibody Seroconversion Rate (SCR)
Timeframe: From Day 1 to Day 22
Percentage of Participants With Anti-vaccine Antibody Seroprotection Rate (SPR)
Timeframe: At Day 22