Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implanta… (NCT05437471) | Clinical Trial Compass
CompletedNot Applicable
Effects of Co-treatment on Endometrial abv3-integrin Expressions in Women With Recurrent Implantation Failure
Malaysia39 participantsStarted 2020-01-01
Plain-language summary
To compare the abv3-integrin expression in endometrium tissue among RIF women between the GnRH analogue with Aromatase Inhibitor (Group A) , GnRH analogue with progesterone (Group B) and GnRH analogue alone as control group (Group C)
Who can participate
Age range18 Years – 40 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Women of 18 to 40 years of age
* No significant pre-existing major medical.
* Diagnosed as recurrent implantation failure - at least two or more failure of achieving pregnancy following embryo transfer (ET) despite the optimum endometrial thickness and good quality of embryo (unexplained).
* Regular menstrual cycle atleast 3 months prior to treatment
* Not taking any hormonal treatment for atlest 3months prior to recruitment
* Agreed to participate
Exclusion Criteria:
* Concurrent significant pre-existing major medical conditions such as uncontrolled diabetes, active systemic lupus erythematosus (SLE) or Anti Phospholipid Syndrome (APS) that will interfere with implantation.
* Poor quality of embryo
* Suboptimal endometrial thickness(\<8mm) during the embryo transfer (ET).
* On hormonal therapy prior to recruitment.
* Not agreed to participate
What they're measuring
1
endometrial abv3-integrin expression expressions
Timeframe: 12 months
Trial details
NCT IDNCT05437471
SponsorUniversiti Kebangsaan Malaysia Medical Centre