Treatment, Emotion, and Neuromodulation of Depression (TREND) Study (NCT05436379) | Clinical Trial Compass
CompletedNot Applicable
Treatment, Emotion, and Neuromodulation of Depression (TREND) Study
United States21 participantsStarted 2022-06-17
Plain-language summary
The investigators will administer theta burst stimulation (TBS) in efforts to observe a decrease in severity of reported depression symptoms. A subset of participants will receive positive affect training during this intervention.
Who can participate
Age range18 Years – 26 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Current Diagnostic and Statistical Manual (DSM-5) Depressive Disorder
Exclusion Criteria:
* Bipolar disorder (lifetime)
* Obsessive-compulsive disorder (lifetime)
* History of psychosis
* Daily use of nicotine
* Past-month use of cocaine, amphetamines, Methyl enedioxy methamphetamine (MDMA), Phencyclidine (PCP), Ketamine, or gamma-hydroxybutyrate (GHB)
* Past 6 month substance use disorder
* Binge drinking (using NIAAA criteria) within the past week, alcohol use in the past 12 hours
* Neurological disorders: Epilepsy, Parkinson's Disease, brain tumor, brain injury, stroke
* History of head trauma with a loss of consciousness (e.g., concussion)
* History of seizures
* MRI contraindications: body shape/size too large to fit in scanner, claustrophobia, and ferromagnetic metal in the body
* Pregnancy
* Current use of Clozapine, Bupropion, or prescription stimulants
* Current use of benzodiazepines or mood stabilizers
* Body shape/size too large to fit in MRI scanner
* Claustrophobia
* Metal in the head or ferromagnetic metal in the rest of the body
* Implanted medical devices
* High-risk suicidality