A Study of the KIO-201 (Ocular Bandage Gel) for Improving Persistent Corneal Epithelial Defects

Inclusion Criteria: * Patients 18 years of age or older. * Patients with persistent corneal epithelial defects (PED) (Stage 1 and Stage 2 PED). * Patients with PED in one or both eyes, at least one eye meeting all study criteria. * Have PED of at least 2 weeks' duration refractory to one or more conventional non-surgical treatments for Stage 1 and Stage 2 PED (i.e., preservative-free artificial tears, gels or ointments; discontinuation of preserved topical drops). Exclusion Criteria: * Have any active ocular infection (bacterial, viral, fungal or protozoal) in the affected eye(s). * Schirmer's test without anesthesia ≤ 3 mm/ 5 minutes in the affected eye(s). * Patients who have received amniotic membrane transplantation and have not healed. * Patients treated with a bandage contact lens but have not healed. * Prior surgical procedure(s) for the treatment of PED in the affected eye(s). * Patients with lid abnormalities. * Corneal disease that may affect outcomes. * Stage 3 PED.