Aerobic exercise has emerged as an effective treatment to reduce sport-related concussion symptom severity, yet existing work lacks rigor regarding the precise exercise volume and intensity required to elicit therapeutic effects, how exercise can alter concussion-related pathophysiology, and whether exercise can prevent the development of secondary sequelae. Our objective is to examine if a high dose exercise program (higher volume than currently prescribed at an individualized, safe intensity level) initiated within 14 days of concussion results in faster symptom resolution, altered physiological function, or reduced secondary sequalae. Findings from this research will lead to more rigorous and precise rehabilitation guidelines and improved understanding about how exercise affects neurophysiological function among adolescents with concussion.
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Time from injury to symptom resolution
Timeframe: From time of injury until defined symptom resolution observed, about 30 days
Serum biomarker concentration: GFAP change
Timeframe: Baseline, Visit 2 (scheduled after symptoms resolve, about 35 days post-baseline)
Anxiety and depression severity change
Timeframe: Baseline, Visit 2 (scheduled after symptoms resolve, about 35 days post-baseline)