Feasibility of Slow Continuous UltraFiltration For Deresuscitation in Critically Ill Patients

Inclusion Criteria: * Adults (\>18 years) * Evidence of fluid overload (greater than trace amount of peripheral oedema in \>1 site, pulmonary oedema on chest radiograph, or positive fluid balance equivalent to \>5% body weight) * Clinician intention to target a negative fluid balance * Expected to remain in a critical care setting beyond the next calendar day Exclusion Criteria: Anticipated unavailability of suitable vascular access * Lack of commitment to full support * Receiving or imminently planned to receive renal replacement therapy * Hyponatraemia (Sodium \<130mmol/L) * Hypernatraemia (Sodium \>150mmol/L) * Significant metabolic alkalosis (Bicarbonate\>30 and pH\>7.5) * Significant metabolic acidosis (HCO3- \<18 mmol/l and pH \< 7.30) * Uncorrected hypokalaemia (Potassium \<3.0mmol/L) * Liver failure (Child-Pugh Grade B or above) * Shock (any of: lactate \>3mmol/L, extensive skin mottling, central capillary refill time\>3 seconds, more than 1 vasoactive agent in use, noradrenaline dose \>0.2 mcg/kg/min, use of dobutamine, adrenaline, milrinone, enoximone or levosimendan) * Receiving any systemic anticoagulation other than for routine venous thromboembolism prophylaxis, or dual antiplatelet therapy * Prisoner * Known pregnancy