Role of Screening With Coronary Computed Tomography Angiography in Primary Prevention of Coronary… (NCT05431309) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Role of Screening With Coronary Computed Tomography Angiography in Primary Prevention of Coronary Heart Disease
15,000 participantsStarted 2022-07-01
Plain-language summary
The primary objective of this study is to determine whether coronary computed tomography angiography (CCTA) -based coronary heart disease(CHD) prevention strategy will be superior to traditional CHD prevention strategy, in reducing the future risk of CHD which included myocardial infarction, angina, cardiac death, and an emergency/urgent coronary revascularisation procedure, in a community population aged 40 to 69 years with cardiovascular risk factors but no history of cardiovascular disease.
Who can participate
Age range40 Years – 69 Years
SexALL
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Inclusion criteria
✓. Resident population aged 40-69 in Nanjing, China
✓. One or more of the following cardiovascular disease risk factors must be present, as follows:
✓. Current or recent (within 12 months) smoker
✓. Clinical diagnosis of hypertension (\>140/90mmHg)
✓. Hypercholesterolaemia (LDL≥4.1mmol/L or total cholesterol\>6.0 mmol/L, including familial hypercholesterolaemia)
✓. Diabetes mellitus
✓. Rheumatoid arthritis
✓. Systemic lupus erythematosus
Exclusion criteria
✕. Plan to leave Nanjing within 5 years or be unable to complete the follow-up work
✕. Refuse to sign informed consent or inability to understand and comply with the program process
✕. Serious liver disease or dysfunction (chronic active hepatitis and cirrhosis, or aspartate aminotransferase (AST) or alanine transaminase (ALT) \> 3 times the upper limit of normal)