Dose-Ranging Trial of Inhaled Cannabis for Acute Migraine Treatment

Inclusion Criteria: * Age ≥ 21 and ≤ 65 * Able to communicate in English * Migraine, with or without aura, in its episodic or chronic manifestations, as per the International Headache Society (IHS) classification International Classification of Headache Disorders (ICHD-3) criteria (section 1.1, 1.2, 1.3).(48) * Ability to provide informed consent and complete website questionnaires in English * Agrees not to use cannabis outside of the study during participation in the study * Agrees not to use opioids or barbiturates during participation in the study * Agrees not to drive a motor vehicle within 4.5 hours following last use of inhaled cannabis during participation in the study Exclusion Criteria: * Positive urine drug test for THC, barbiturates, opioids, oxycodone, or methadone prior to enrollment * Pregnancy * Breastfeeding * Prisoner * Known cognitive impairment * Institutionalized * Current moderate-severe or severe depression * Current or past history of bipolar depression, schizophrenia, or psychosis * Current or past history of cannabis, alcohol, opioid, or amphetamine abuse or other substance use disorder at the discretion of the research team * Active pulmonary disease, class IV heart failure, cirrhosis, or other severe medical illnesses at the discretion of the research team. * Allergy to cannabis