Canagliflozin Targeting Vascular Inflammation

Exclusion criteria

• ✕. severe LV dysfunction (EF\<50%);
• ✕. decompensated heart failure;
• ✕. active infection (e.g. pneumonia, active skin infections, and on antibiotics);
• ✕. active inflammatory conditions (e.g. rheumatoid arthritis, chronic inflammatory bowel disease, SLE, systemic anti-inflammatory therapy (e.g. prednisone, methotrexate));
• ✕. pregnancy (all women of child bearing potential will have a negative BHCG test;
• ✕. breastfeeding;
• ✕. Women of childbearing potential who refuse to use two forms of contraception (this includes at least one form of highly effective and one effective method of contraception) throughout the study OR men capable of fathering a child who refuse to use contraception.
• ✕. glomerular filtration rate (GFR) \<50 ml/min/1.72m2;