Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylatio… (NCT05415670) | Clinical Trial Compass
CompletedNot Applicable
Benign/Malignant Pulmonary Nodule Classification Based on High-throughput Whole-genome Methylation Sequencing(GM-seq)
China158 participantsStarted 2023-07-01
Plain-language summary
Lung cancer is the first cancer in China in terms of morbidity and mortality. The problem of early diagnosis/treatment has always been concerned. The popularization of chest CT (electronic computed tomography) screening makes it possible to detect lung cancer early. However, the diagnosis still needs pathological evidence. It is an ideal choice to obtain pathological evidence through bronchoscope and other minimally invasive means before surgical resection. However, the positive rate of tracheoscopy is still unsatisfactory, which is related to the difficulty of traditional pathological detection in detecting small specimens obtained by tracheoscopy. Liquid biopsy technology based on methylation detection has been used in early cancer screening, but its advantages have not been fully exploited due to the low content of ctDNA (circulating tumor DNA) in the current detection samples. Therefore, through prospective clinical research, the investigators plan to combine the methylation detection technology based on "Whole genome methylation sequencing(GM-seq)" with tracheoscopy, compare the traditional pathological methods with methylation detection on the bronchoscopic samples of lung nodule subjects suspected of early lung cancer, and take the postoperative pathology as the gold standard for judging benign and malignant, to confirm the feasibility and advantages of the new technology.
Who can participate
Age range20 Years – 75 Years
SexALL
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Inclusion criteria
✓. Male or female, 20-75 year-old with pulmonary nodules 1-3cm in diameter confirmed by chest CT;
✓. The nodules are single or multiple, suspected to be malignant, and have the indication of surgical resection;
✓. Patient accept imaging evaluation without advanced lung tumors and metastases;
✓. The location of the nodule in the lung is within the reach of lung biopsy under bronchoscope;
✓. provide the collected clinical data needed by the research;
✓. Patients have the ability to follow the planned schedule and actively cooperate to return to the hospital for regular clinical visits.
Exclusion criteria
✕. Unwilling to accept the invasive examination and treatment of this study;
✕. Contraindication of tracheoscopy;
✕. Consider that the pulmonary nodules are metastatic tumors or unresectable advanced lung cancer;
What they're measuring
1
Area under the receiver operating characteristic curve (ROC)