CompletedPhase 4

Diuretic Treatment in Acute Heart Failure With Volume Overload Guided by Serial Spot Urine Sodium Assessment

Belgium107 participantsStarted 2022-06-12

Plain-language summary

This is a pragmatic, multicenter, interventional, parallel-arm, randomized, open-label trial to investigate whether a diuretic regimen, based on serial assessment of sodium concentration (UNa) on spot urine samples after diuretic administration and with low-threshold use of combination diuretic therapy, improves decongestion versus usual care in acute heart failure (AHF), potentially leading to better clinical outcomes.

Who can participate

Age range18 Years – 99 Years

SexALL

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Inclusion criteria

✓. bilateral oedema 2+, indicating clear pitting
✓. ascites that is amenable for drainage, confirmed by echography (no obligation to perform abdominal echocardiography, but necessary when presence of ascites is used as an entry criterion for the study)
✓. uni- or bilateral pleural effusions that are amenable for drainage, confirmed by chest X-ray or lung ultrasound (no obligation to perform chest X-ray, but necessary when presence of pleural effusions is used as an entry criterion for the study)

What they're measuring

Mortality, Days in Hospital & Decongestion

Timeframe: 30 days

Trial details

NCT IDNCT05411991

SponsorVrije Universiteit Brussel

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2024-07-01

Results submitted2025-06-30

View on ClinicalTrials.gov More Acute Heart Failure trials