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Study Summary Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative surgical pain control Short Title Pharmacokinetic profile of lidocaine given as a weight-based infusion for postoperative surgical pain control Methodology Pharmacokinetic study of lidocaine in the surgical population Study Duration 1 year Study Center(s) University of Alberta Hospital Objectives The primary objective will be to map serum lidocaine levels over time in a diverse surgical patient population receiving a weight-based lidocaine infusion. Number of Subjects 40 Diagnosis and Main Inclusion Criteria ASA class 1-3 Age 18-40 or \>75 Scheduled for elective major ENT flap, urology or general surgery. Study Product, Dose, Route, Regimen Lidocaine IV infusion * 1.5mg/kg bolus, then * 1mg/kg/h IV intraoperatively, then * 0.5-2 mg/kg/hr IV for 48 h, depending on clinical response
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Lidocaine concentrations from plasma samples
Timeframe: 48 hours from initiation of lidocaine infusion