This study seeks to determine the safety and efficacy of the infusion of autologous CD19 CAR-T cells that are manufactured using an ultra-fast process.
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Phase 1: Recommended dose(s) of UF-KURE19 CAR-T Cells
Timeframe: Up to 28 days after treatment
Phase 1: Toxicities associated with the target dose of UF-KURE19 CAR-T Cells
Timeframe: Up to 12 months after treatment
Phase 1b: Toxicities associated with the target dose of UFKURE19 in patients with Relapsed or Refractory Large B-cell Lymphoma (LBCL).
Timeframe: Up to 12 months after treatment
Phase 1b: Complete response rate (CRR) with UF-KURE19 in patients with Relapsed or Refractory LBCL.
Timeframe: Up to 12 months after treatment
Phase 1b: Objective response rate (ORR, CR + PR) with UF-KURE19 in patients with Relapsed or Refractory LBCL.
Timeframe: Up to 12 months after treatment
Phase 1b: CRR in double/triple hit lymphoma (DHL/THL) patients treated with first-line standard of care chemoimmunotherapy PLUS early intervention of UFKURE19.
Timeframe: Up to 12 months after treatment