WithdrawnPhase 4

Can Nitrous Oxide (Laughing Gas) be Used as a Sedative for GI Endoscopy Procedures?

Stopped: We do not have access to the patient population anymore due to a move in our operational design

United States0Started 2024-05-01

Plain-language summary

Nitrous oxide (commonly known as 'laughing gas') is often used during dental and other outpatient procedures, because it is easy to administer, is short-acting and rapidly clears from the body following the procedure. The investigators hypothesize that use of Nitrous oxide during GI endoscopy may enhance patient comfort during the procedure and speed-up post-procedure recovery, while minimizing the fatigue and mental fogginess some patients report the day after receiving standard sedative and narcotic drugs used routinely for the procedure. The investigators are interested in determining if adding Nitrous Oxide to commonly used sedation drugs will decrease fatigue, mental fogginess, and nausea/vomiting, as well as determine when the patient felt fully recovered from the effects of all sedatives given for the procedure.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Non-pregnant patients age 18 and older * Patient's presenting for upper endoscopy or colonoscopy under endoscopist- directed nurse sedation. * Patient is willing and able to consent and comply with study procedures. Exclusion Criteria: * Age \<18 * Potentially vulnerable subjects including, homeless people, pregnant females, employees and students. * Participation in another investigational study that may directly or indirectly affect the results of this study within 30 days prior to the initial visit * Allergy to the proposed anesthetic agents (e.g. nitrous oxide, midazolam, fentanyl, diphenhydramine)

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Intravenous sedative drug

Timeframe: Duration of the procedure (1-2 hours)

Recovery time

Timeframe: Duration of the procedure (1-3hours)

Patient comfort

Timeframe: Duration of the procedure (1-3hours)

Fatigue

Timeframe: 24-36 hours

Fatigue

Timeframe: 24-36 hours

Nausea/vomiting

Timeframe: 24-36 hours

Nausea/vomiting

Timeframe: 24-36 hours

Mental Fogginess post-procedure/sedation

Timeframe: 24-36 hours

Trial details

NCT IDNCT05396144

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-08-31

View on ClinicalTrials.gov More Endoscopy trials

Plain-language summary

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Intravenous sedative drug

Timeframe: Duration of the procedure (1-2 hours)

Recovery time

Timeframe: Duration of the procedure (1-3hours)

Patient comfort

Timeframe: Duration of the procedure (1-3hours)

Fatigue

Timeframe: 24-36 hours

Fatigue

Timeframe: 24-36 hours

Nausea/vomiting

Timeframe: 24-36 hours

Nausea/vomiting

Timeframe: 24-36 hours

Mental Fogginess post-procedure/sedation

Timeframe: 24-36 hours