CompletedNot Applicable

Leucine Requirement in Adult Men and Women

Canada32 participantsStarted 2022-04-29

Plain-language summary

The purpose of the study is to determine the body's nutritional need for the essential amino acid, leucine, in adult men and women 18 to 39 years of age.

Who can participate

Age range18 Years – 39 Years

SexALL

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Inclusion criteria

✓. Healthy adult males, 18 to 39 years of age.
✓. Healthy adult females, 18 to 39 years of age with regular menstrual cycles within in the last 12 months.
✓. Willingness to participate in the study and completed the screening procedures (height, weight, fasting blood sample and medical history questionnaire).
✓. No recent history of weight loss
✓. BMI between 18.5 - 27 kg/m 2
✓. Absence of chronic disease or acute illness that could affect protein and AA metabolism (diabetes, cancer, liver or kidney disease, HIV, acute cold or flu, COVID-19, hypo or hyperthyroidism, rheumatoid arthritis treated with anti-inflammatory medications).
✓. Non-smoking
✓. Willingness to consume the diet provided.

Exclusion criteria

✕. Presence of disease known to affect protein and AA metabolism (diabetes, cancer, liver or kidney disease, HIV, acute cold or flu, Covid-19, hypo or hyperthyroidism, rheumatoid arthritis treated with anti-inflammatory medications).
✕. On medications known to affect protein and amino acid metabolism (steroids) or taking oral contraceptive pills or other birth control devices that would affect sex hormone profiles over the last 2 years.
✕. Pregnant or lactating women.
✕. Recent significant weight loss; ≥ 5% of body with in the last 3 months.
✕. Individuals on weight reducing diets.
✕. Inability to tolerate the diet
✕. Unwilling to have blood drawn from a venous access, or using a ventilated hood indirect calorimeter for the purposes of the study.
✕. Significant coffee consumption of more than 2 cups/day

What they're measuring

F13CO2

Timeframe: 4.5 hours during study visits

Trial details

NCT IDNCT05394155

SponsorThe Hospital for Sick Children

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2023-12-31

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