Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy (NCT05383300) | Clinical Trial Compass
CompletedNot Applicable
Intranasal Oxytocin in Antiosocial Personality Disorder and Psychopathy
United Kingdom72 participantsStarted 2017-05-01
Plain-language summary
A pharmacoimaging study of oxytcoin in antisocial personality disorder and psychopathy
Who can participate
Age range18 Years – 60 Years
SexMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male
* Aged 18-60
* IQ greater than 70 as defined by the Wechsler Abbreviated Scale of Intelligence (WASI-II).
Violent offenders:
Offenders with convictions for violent crimes (murder, rape, attempted murder, grievous and actual bodily harm) who met DSM-5 criteria for antisocial personality disorder (Structured Clinical Interview for DSM-5 Personality Disorders (SCID-5 PD) Psychopathy or non-psychopathy subgroup based on Psychopathy Checklist- Revised (PCL-R; (Hare, 2003))- score of 25 as the threshold for psychopathy in this English population.
Healthy non-offenders:
Non-offenders with no personality disorder
Exclusion criteria:
* history of major mental disorders (bipolar 1, bipolar 2, major depression or psychotic disorders)
* self-reported neurological disorders
* head injury resulting in loss of consciousness for 1 hour or longer
* severe visual or hearing impairments
* contraindications to MRI
What they're measuring
1
Within-group effect of oxytocin on nerual modulation of fear