Endodontic Microsurgery With the Use of L-PRF Block

Inclusion Criteria * Provision of Informed Consent * Patients from 18 years old * Patients in need of an EMS * EMS is the only option to cure the periapical lesion * A periapical lesion that has a diameter of 10mm or more in sagittal plane, frontal plane or axial plane when measured on CBCT Exclusion Criteria * Unlikely to be able to comply with the study procedures, as judged by the investigator * Orthograde endodontic (re)treatment is indicated * Known or suspected current malignancy * History of chemotherapy within 5 years prior to study * History of radiation in the head and neck region * History of other metabolic bone diseases * History of bleeding disorders * HIV disease * Hepatitis B or C * Systemic disease (osteoporosis, diabetes…)