The primary objective of the Vanderbilt Alzheimer's Disease Research Center (VADRC) is to provide local and national researchers with access to a well-characterized and diverse clinical cohort, including participant referrals, biosamples, clinical data, and neuroimaging data. The VADRC Clinical Core will create an infrastructure to support research efforts of both local and national investigator studies to develop early detection, prevention, and treatment strategies for Alzheimer's disease. The Clinical Core intends to enroll up to 1000 participants, including individuals who are cognitively unimpaired, have mild cognitive impairment, or have Alzheimer's disease. This cohort of about 1000 participants will be called the Tennessee Alzheimer's Project. Participants will be seen annually for comprehensive clinical characterization and then referred to other studies to enhance Alzheimer's disease research activities.
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Cognitive status
Timeframe: baseline to year 3
APOE Genotype
Timeframe: baseline to year 3
White matter hyperintensities Volume
Timeframe: baseline to year three
Grey Matter Volume
Timeframe: baseline to year three
Cerebral Blood Flow
Timeframe: baseline to year three
Lacunar infarcts
Timeframe: baseline to year three
Microbleeds
Timeframe: baseline to year three
Left ventricular ejection fraction
Timeframe: baseline to year three
Cardiac output
Timeframe: baseline to year three
Stroke volume
Timeframe: baseline to year three
Heart rate
Timeframe: baseline to year three
Biological markers for Alzheimer's disease
Timeframe: baseline to year three
Blood based biological marker for Alzheimer's disease
Timeframe: baseline to year three