This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with spinal cord injury (SCI).
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Targeted TCSCS map modulate resting blood pressure (BP)
Timeframe: Week 1-2 (once)
Targeted TCSCS map to activate skeletal muscles and pelvic floor muscles
Timeframe: Week 1-2 (once)
Immediate change in BP during the head up tilt test (HUTT)
Timeframe: Week 3 - 6 (once)
Change in BP during the head up tilt test (HUTT) from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in BP during the head up tilt test (HUTT) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in BP during digital anorectal stimulation (DARS)
Timeframe: Week 3 - 6 (once)
Change in BP during digital anorectal stimulation (DARS) from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in BP during digital anorectal stimulation (DARS) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in rectal pressure measured by anorectal manometry (ARM)
Timeframe: Week 3 - 6 (once)
Immediate change in high pressure anal canal zone measured by ARM
Timeframe: Week 3 - 6 (once)
Immediate change in recto-anal inhibitory reflex measured by ARM
Timeframe: Week 3 - 6 (once)
Immediate change in rectal sensation measured by ARM
Timeframe: Week 3 - 6 (once)
Change in rectal pressure measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in high pressure anal canal zone measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in rectal sensation measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in recto-anal inhibitory reflex measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in rectal pressure measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in high pressure anal canal zone measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in recto-anal inhibitory reflex measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in rectal sensation measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in intravesical pressure at first sensation measured by urodynamic investigation (UDI)
Timeframe: Week 3 - 6 (once)
Immediate change in intravesical pressure at leakage point measured by UDI
Timeframe: Week 3 - 6 (once)
Immediate change in intravesical pressure at maximal volume measured by UDI
Timeframe: Week 3 - 6 (once)
Change in intravesical pressure at first sensation measured by UDI from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in intravesical pressure at leakage point measured by UDI from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in intravesical pressure at maximal volume measured by UDI from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in intravesical pressure at first sensation measured by UDI from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in intravesical pressure at leakage point measured by UDI from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in intravesical pressure at maximal volume measured by UDI from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in BP during penile or clitoral vibrostimulation
Timeframe: Week 3 - 6 (once)
Change in BP during penile or clitoral vibrostimulation from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in BP during penile or clitoral vibrostimulation from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Baseline assessment of colonic motility using the wireless motility capsule
Timeframe: Week 3 - 6 (once)
Change in colonic motility using the wireless motility capsule from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in colonic motility using the wireless motility capsule from baseline to 8 weeks after TCSCS cessation.
Timeframe: Week 27-30 (once)