This study is a pilot clinical trial to explore the efficacy of transcutaneous spinal cord stimulation (TCSCS) (proof-of-concept) in mitigating crucial autonomic dysfunctions that impact the health-related quality of life of individuals with spinal cord injury (SCI).
Age range
19 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Targeted TCSCS map modulate resting blood pressure (BP)
Timeframe: Week 1-2 (once)
Targeted TCSCS map to activate skeletal muscles and pelvic floor muscles
Timeframe: Week 1-2 (once)
Immediate change in BP during the head up tilt test (HUTT)
Timeframe: Week 3 - 6 (once)
Change in BP during the head up tilt test (HUTT) from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in BP during the head up tilt test (HUTT) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in BP during digital anorectal stimulation (DARS)
Timeframe: Week 3 - 6 (once)
Change in BP during digital anorectal stimulation (DARS) from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in BP during digital anorectal stimulation (DARS) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in rectal pressure measured by anorectal manometry (ARM)
Timeframe: Week 3 - 6 (once)
Immediate change in high pressure anal canal zone measured by ARM
Timeframe: Week 3 - 6 (once)
Immediate change in recto-anal inhibitory reflex measured by ARM
Timeframe: Week 3 - 6 (once)
Immediate change in rectal sensation measured by ARM
Timeframe: Week 3 - 6 (once)
Change in rectal pressure measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in high pressure anal canal zone measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in rectal sensation measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in recto-anal inhibitory reflex measured by ARM from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in rectal pressure measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in high pressure anal canal zone measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in recto-anal inhibitory reflex measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in rectal sensation measured by anorectal manometry (ARM) from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in intravesical pressure at first sensation measured by urodynamic investigation (UDI)
Timeframe: Week 3 - 6 (once)
Immediate change in intravesical pressure at leakage point measured by UDI
Timeframe: Week 3 - 6 (once)
Immediate change in intravesical pressure at maximal volume measured by UDI
Timeframe: Week 3 - 6 (once)
Change in intravesical pressure at first sensation measured by UDI from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in intravesical pressure at leakage point measured by UDI from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in intravesical pressure at maximal volume measured by UDI from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in intravesical pressure at first sensation measured by UDI from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in intravesical pressure at leakage point measured by UDI from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Change in intravesical pressure at maximal volume measured by UDI from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Immediate change in BP during penile or clitoral vibrostimulation
Timeframe: Week 3 - 6 (once)
Change in BP during penile or clitoral vibrostimulation from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in BP during penile or clitoral vibrostimulation from baseline to 8 weeks after cessation of TCSCS
Timeframe: Week 27-30 (once)
Baseline assessment of colonic motility using the wireless motility capsule
Timeframe: Week 3 - 6 (once)
Change in colonic motility using the wireless motility capsule from baseline to after completion of 8 weeks of TCSCS
Timeframe: Week 15-18 (once)
Change in colonic motility using the wireless motility capsule from baseline to 8 weeks after TCSCS cessation.
Timeframe: Week 27-30 (once)