The Value of IVL Compared To OPN Non-Compliant Balloons for Treatment of RefractorY Coronary Lesions (VICTORY) Trial

Clinical inclusion criteria: * Age ≥18 years and consentable; * Acute or chronic coronary artery disease with ischemia related symptoms (e.g. angina) and/or evidence of myocardial ischemia (e.g. FFR/ iFR, CMR, SPECT or PET-CT); * Angiographically-proven coronary artery disease; * Lesions in non-target vessels requiring PCI may be treated either * prior to the study procedure if the procedure was unsuccessful or complicated; or * in the same session if feasible and safe for the patient, otherwise a staged PCI procedure for non-target vessels may be considered; * Informed Consent signed by the subject. Angiographic inclusion criteria: * Single de novo target lesion stenosis of protected LMCA, or LAD, RCA or LCX (or of their branches) with\*: * Stenosis of ≥70%; * Stenosis ≥50% and \<70% (visually assessed) with evidence of ischemia via positive stress test, or fractional flow reserve value ≤0.80, or iFR \<0.90 or IVUS minimum lumen area ≤4.0 mm²; * The target vessel reference diameter must be ≥2.5 mm \& ≤4.5mm; * AND AT LEAST ONE OF THE FOLLOWING CRITERIA: * Evidence of calcification at the lesion site by angiography (Grade 3), with fluoroscopic radio-opacities noted without cardiac motion prior to contrast injection involving both sides of the arterial wall in at least one location and total length of calcium of at least 15 mm and extending partially into the target lesion, * AND/ OR by OCT, with presence of ≥270° calcium; * AND/ OR Prior attempt at PCI wit…