FotonaSmooth Erbium:YAG Laser for the Treatment of Urethral Pain Syndrome in Women

Inclusion Criteria: * Adult female, 18 years of age or older * Urethral pressure pain upon palpation, VAS Score ≥ 2 * Intermittent or chronic pain in the urethra and/or the small pelvis (independent of micturition) for at least 6 months * No significant improvement of UPS from at least one previous conservative treatment (pessary, antibiotics, local oestrogens etc.) * Signed informed consent Exclusion Criteria: * Pregnancy * Treatment with Isotretinoin (Acne, Rosacea) within last 6 months * Acute urinary tract infection or other acute infection of the bladder, vagina, vulva or urinary tract detected by routine urine analysis * Positive urethral swab for Ureaplasma, Mycoplasma or Chlamydia ≤ 6 weeks. Exception: Patients with chronic and persistent fastidious bacteria can be included six weeks after two unsuccessful treatments with antibiotics. Antibiotics therapy must also include sexual partners. * Pre-existing bladder or urethra pathology * Interstitial Cystitis * Endometriosis * Diagnosis of collagen disorders, e.g. benign joint hypermobility / Elhers-Danlos / Marfans etc. * Vesicovaginal fistula * Unwillingness or inability to complete follow-up schedule * Unwillingness or inability to give informed consent * Unwillingness or inability to complete questionnaires