This is a 5-week crossover pilot study of 15 highly motivated healthy volunteers who will consume two 7-day intervention diets: 1) a diet low in sulfur-containing amino acids (Low-S diet), emphasizing plant-based foods and fat sources; and 2) a diet high in sulfur-containing amino acids (High-S diet), emphasizing animal protein and fat sources. A 14-day washout period will follow each intervention, in which participants will eat their typical diets.
Who can participate
Age range18 Years – 80 Years
SexALL
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Inclusion Criteria:
* Provide informed consent
* Ambulatory and community dwelling
* Able and willing to comply with the study schedule and procedures
* 18 - 80 years of age
* BMI between 18.5 - 40.0 kg/m2
* Omnivorous or willing to consume animal products through duration of study
Exclusion Criteria:
* Antibiotic use within 3 months
* Planned antibiotic therapy within the period of the study, e.g., perioperative antibiotics.
* Use of sulfonamides or sulfasalazine, as these sulfur-containing medications may confound results
* Use of 5-aminosalicylates (5-ASA), as they are known to inhibit sulfidogenesis
* History of anaphylactic food allergies, e.g., peanuts, seafood.
* Food intolerances and allergies, including gluten sensitivity, lactose intolerance, and intolerance of high fiber dietary content.
* Strict vegan eating practices, with refusal to consume animal products.
* Planned use of oral probiotics while on study.
* Serious, concomitant illness that, in the opinion of the Investigator, would interfere with evaluation of safety or efficacy, or put the participant at risk of harm from study participation.
* Significant alcohol use, defined as \> 20 g/day in females and \> 30 g/day in males for a period of 3 months within one year prior to screening.
* Underlying chronic gastrointestinal disease that can cause diarrhea, including short bowel syndrome, irritable bowel syndrome, malabsorption, and celiac disease.
* History of partial or complete colectomy.
* History of mal…
What they're measuring
1
Effect of Short-term (1-week) Plant- and Animal-based Eating Patterns on Hydrogen Sulfide Production
Timeframe: Following 1-week of plant- and animal-based eating patterns