CIPHER Study: Pilot Study to Study the Role of ctDNA in Triple Negative and HER2 Positive Early Stage

Inclusion Criteria: * Participants with a diagnosis of clinical Stage II-III triple negative and/or HER2 positive breast cancer * Age ≥ 18 years * Estimated life expectancy of at least twelve months * Participant must be eligible for neoadjuvant systemic therapy per treating physician * Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2 * Able to provide signed and dated informed consent form * Must have ctDNA at the time of screening to be eligible for the study * Participants enrolled on other systemic therapy trials may be eligible to participate in the study after discussion with principal investigator * Be willing to present for medical exams and blood draws as scheduled per protocol Exclusion Criteria: * Evidence of metastatic breast cancer * Any other concurrent malignancy * Prior malignancies (except non-melanoma skin cancers, and the following in situ cancers: bladder, gastric, colon, endometrial, cervical/dysplasia, melanoma, or breast) unless a complete remission was achieved at least one year prior to study entry * Participant is pregnant * Serious concomitant systemic disorder that would compromise the safety of the participant or compromise the participant's ability to complete the study, at the discretion of the investigator * Bone marrow transplant or other organ transplant recipient * History of psychiatric illness or social situations that would limit compliance with study requirements * Has a history or current evidence of any condition, th…