Proof-of-Concept Interventional Study With a Nasal Spray of JT-1 in Patients With Chronic Rhinitis or Chronic Sinusitis

Inclusion Criteria: * Clinically diagnosed chronic allergic rhinitis or chronic sinusitis with no or a mild status of nasal polyp activity * Disease lasting 12 weeks or longer * Patients with moderate or severe symptoms (SNOT-22 score \>20) * Male or female at least 18 years old * Females in childbearing age are requested to make a pregnancy test and to confirm in writing to take contraceptive measures until Follow-up Visit (Day 49). * Patient understands German Exclusion Criteria: * Severely purulent forms of sinusitis * History of medication during the last four weeks * not allowed: antibiotics, systemic or topical steroids * allowed: nasal saline spray or irrigation, analgesics, decongestants, antihistamines * Patient has a status of moderate or severe polyp activity in the nose * Patient had sinus surgery in the past 6 months * Patient needs O2 substitution * Patient has cystic fibrosis * Patient has primary ciliary dyskinesia * Patient is demented or otherwise incapable of judgement